1-[2-(trifluoromethoxy)phenyl]ethanone

1-[2-(trifluoromethoxy)phenyl]ethanone - Names and Identifiers

Name	2-(trifluoromethoxy)acetophenone
Synonyms	2-(TRIFLUOROMETHOXY)ACETOPHENONE 2-(trifluoromethoxy)acetophenone 2'-(TRIFLUOROMETHOXY)ACETOPHENONE 2'-(Trifluoromethoxy)acetophenone 1-(2-(TrifluoroMethoxy)phenyl)ethanone 1-[2-(trifluoromethoxy)phenyl]ethanone Ethanone, 1-[2-(trifluoromethoxy)phenyl]- 1-[2-(Trifluoromethoxy)phenyl]ethan-1-one
CAS	220227-93-0
EINECS	642-468-4
InChI	InChI=1/C9H7F3O2/c1-6(13)7-4-2-3-5-8(7)14-9(10,11)12/h2-5H,1H3

1-[2-(trifluoromethoxy)phenyl]ethanone - Physico-chemical Properties

Molecular Formula	C9H7F3O2
Molar Mass	204.15
Density	1,265 g/cm3
Boling Point	191.7±35.0 °C(Predicted)
Flash Point	68.2°C
Vapor Presure	0.509mmHg at 25°C
Appearance	clear liquid
Color	Colorless to Light yellow
BRN	2259035
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.45
MDL	MFCD00236320

1-[2-(trifluoromethoxy)phenyl]ethanone - Risk and Safety

Hazard Symbols	Xi - Irritant
Safety Description	S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes.
HS Code	29147000
Hazard Class	IRRITANT

1-[2-(trifluoromethoxy)phenyl]ethanone - Introduction

2-(trifluoromethoxy)acetophenone is an organic compound with the chemical formula C9H7O2CF3. The following is a description of its nature, use, preparation and safety information:

Nature:
2-(trifluoromethoxy)acetophenone is a colorless and transparent liquid with a special aroma. It has a melting point of -29°C, a boiling point of 133-134°C and a density of 1.331g/cm³. It is soluble in organic solvents such as ethanol, acetone and dimethylformamide at normal temperature.

Use:
2-(trifluoromethoxy)acetophenone is commonly used as an intermediate in organic synthesis. It can be used as a raw material for the synthesis of drugs or pesticides, and can also be used in the preparation of organic optoelectronic devices. In addition, it can also be used as a component of spices and fragrances.

Method:
There are two main methods for preparing 2-(trifluoromethoxy)acetophenone. One method is to obtain 2-(trifluoromethoxy) acetyl chloride by reaction of trifluoromethyl alcohol and Chloroacetyl Chloride, and then react with aniline to generate 2-(trifluoromethoxy) phenylacetamide, finally, the target product was obtained by acid-catalyzed hydrolysis reaction. Another method is to diazotization of benzoic acid as raw material to produce diazotized benzoic acid methyl ester, which is then reacted with trifluoromethyl ether to obtain 2-(trifluoromethoxy)acetophenone.

Safety Information:
2-(trifluoromethoxy)acetophenone is a flammable liquid at room temperature and forms a flammable mixture when contacted with air. Its vapors can cause eye and respiratory irritation and may cause headaches, dizziness and coughing. Therefore, care should be taken to avoid contact with skin and eyes during handling and storage, and protective gloves and goggles should be worn when necessary. In addition, it should be used in a well-ventilated place, away from fire and heat sources. If inhaled or ingested, seek medical attention.

Last Update：2024-04-09 20:52:54